MGED WORK GROUP

TWG Translational & Whole-System Genomics

A scientific framework for connecting genomic information, molecular changes, cellular responses, biological systems, and translational research.

01
Scientific Scope

Connecting Genomic Information Across Biological Systems

TWG focuses on understanding genomic information within broader biological systems. The work group connects genome-level observations with molecular processes, cellular responses, phenotypic changes, and biological organization.

Its scope extends from molecular and genomic measurements toward system-level interpretation, providing a framework for examining how genetic information contributes to biological states and responses across different levels of organization.

02
Core Areas

Whole-System Genomics Domains

01

Systems Genomics

Examining genomic information in relation to molecular, cellular, and biological system-level processes.

02

Molecular Responses

Characterizing changes in molecular activity associated with genetic, environmental, or biological conditions.

03

Phenotypic Relationships

Connecting genomic and molecular observations with measurable cellular and organism-level phenotypes.

04

Translational Genomics

Exploring how genomic knowledge can contribute to biological understanding and translational research.

03
Systems Framework

From Genomic Information to Biological Systems

01

Genomic Information

Identify genomic features, genetic variation, and genome-level information relevant to the biological question.

02

Molecular Processes

Examine changes in gene activity, molecular interactions, and regulatory processes associated with genomic states.

03

Cellular Responses

Investigate how molecular changes influence cellular functions, states, and responses.

04

System-Level Interpretation

Integrate molecular and cellular evidence to understand biological systems and their measurable phenotypes.

04
Research Perspectives

Understanding Biology Across Multiple Levels

01

Genome to Molecule

Linking genomic features with molecular activity, regulation, and biological mechanisms.

02

Molecule to Cell

Exploring how molecular changes contribute to cellular states and functional responses.

03

Cell to System

Connecting cellular behavior with larger biological networks and system-level processes.

04

System to Translation

Relating system-level genomic knowledge to broader biological and translational research questions.

SCIENTIFIC INTEGRATION
Genome Genetic Information
→
Molecule Molecular Processes
→
Cell Cellular Responses
→
System Biological Function

Connecting genomic evidence across biological levels to understand system-level function.